| Details |
| Disease Name | Glioblastoma |
| Nocoding RNA Name | hsa-miR-125a-5p |
| Expression Pattern | down-regulated |
| Species | Homo sapiens |
| Detection Methods | transfection,Luciferase Reporter Assay,Western Blot etc. |
| Target | TAZ |
| Tissue | glioblastoma cell lines |
| Treatment | N/A |
| PubMed ID | 25542152 |
| Year | 2015 |
| Detail Description | miR-125a-5p is an important regulator of TAZ in glioma cells by directly targeting the TAZ 3'UTR. MiR-125a-5p levels are inversely correlated with that of TAZ in normal astrocytes and a panel of glioma cell lines. MiR-125a-5p represses the expression of TAZ target genes, including CTGF and sur-33 vivin, and inhibits cell proliferation and induces the differentiation of GBM cells; whereas over-expres-34 sion of TAZ rescues the effects of miR-125a-5p.miR-125a-5p had the lowest expression in other three high-grade cell lines including U87 MG, T98G and HFU-251 MG. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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