| Details |
| Disease Name | Glioblastoma |
| Nocoding RNA Name | hsa-miR-127-3p |
| Expression Pattern | down-regulated |
| Species | Homo sapiens |
| Detection Methods | sequencing,RT-PCR,Luciferase Reporter Assay etc. |
| Target | RGMA |
| Tissue | brain(brain tumor tissue) |
| Treatment | N/A |
| PubMed ID | 24517116 |
| Year | 2014 |
| Detail Description | using next generation sequencing analysis of miRNAs, we found that miR-127-3p was downregulated in GBM tissues compared with normal brain tissues; we validated this result by RT-PCR. We further showed that DNA demethylation and histone deacetylase inhibition resulted in downregulation of miR-127-3p. miR-127-3p targeted SKI (v-ski sarcoma viral oncogene homolog [avian]), RGMA(RGM domain family, member A), ZWINT (ZW10 interactor, kinetochore protein), SERPINB9 (serpin peptidase inhibitor, clade B [ovalbumin], member 9), and SFRP1 (secreted frizzled-related protein 1). |
NSDNA: The Nervous System Disease NcRNAome Atlas
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