| Details |
| Disease Name | Neuroblastoma |
| Nocoding RNA Name | hsa-miR-128 |
| Expression Pattern | up-regulated |
| Species | Homo sapiens |
| Detection Methods | Real-time PCR,Northern Blot,Luciferase Reporter Assay etc. |
| Target | Reelin |
| Tissue | neuroblastoma cell lines |
| Treatment | N/A |
| PubMed ID | 19713529 |
| Year | 2009 |
| Detail Description | miR-128, a brain-enriched microRNA, in retinoic acid-differentiated neuroblastoma cells, and we found that this microRNA is up-regulated in treated cells, where it down-modulates the expression of two proteins involved in the migratory potential of neural cells: Reelin and DCX. Consistently, miR-128 ectopic overexpression suppressed Reelin and DCX, whereas the LNA antisensemediated miR-128 knockdown caused the two proteins to increase. Ectopic miR-128 overexpression reduced neuroblastoma cell motility and invasiveness, and impaired cell growth. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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