NSDNA: The Nervous System Disease NcRNAome Atlas

Details

Disease Name	Pituitary Neoplasms
Nocoding RNA Name	hsa-miR-128
Expression Pattern	down-regulated
Species	Homo sapiens
Detection Methods	TaqMan miRNA array,RT-PCR,Luciferase Reporter Assay etc.
Target	BMI1
Tissue	brain(pituitary tissues)
Treatment	N/A
PubMed ID	22614013
Year	2013
Detail Description	We identified 17 miRNAs to be differentially expressed between tumors and normal pituitary tissues. Specifically, we found five miRNAs (miR-26b, miR-26a, miR-212, miR-107, and miR-103) to be upregulated and twelve miRNAs (miR-125b,miR-141, miR-144, miR-164, miR-145, miR-143, miR-15b, miR-16,miR-186, let-7b, let-7a3, and miR-128) to be downregulated in twelve pituitary tumors relative to five normal tissues. The miRNA array data were validated by performing miRNA real-time PCR (RT-PCR) analysis. Both analyses revealed that miR-26b and miR-212 were the top two upregulated miRNAs, while let-7a3 and miR-128 were the top two downregulated miRNAs in tumors relative to control tissues, suggesting their potential role in pituitary tumor formation.Furthermore, we identified that miR-26b and miR-128 affected pituitary tumor cell behavior through regulation of their direct targets,PTEN and BMI1,respectively.

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