| Details |
| Disease Name | Astrocytoma |
| Nocoding RNA Name | hsa-miR-129 |
| Expression Pattern | down-regulated |
| Species | Homo sapiens |
| Detection Methods | qRT-PCR etc. |
| Target | N/A |
| Tissue | brain(brain tumor tissue) |
| Treatment | N/A |
| PubMed ID | 18577219 |
| Year | 2008 |
| Detail Description | we used quantitative reverse transcriptase polymerase chain reaction (RTPCR; Taqman) to measure expression of 192 mature miRNA sequences in human non-neoplastic brain tissues (glioses), astrocytomas (AAs) (World Health Organization (WHO) grade III) and Glioblastoma multiforme (GBM)(WHO grade IV). we found 35 miRNAs that were significantly deregulated in AA or GBM tumors. Thirteen (37%) of these miRNAs were differentially expressed in both tumor classes relative to glioses, 16 (45%) were differentially expressed in GBM tumors only, and 6 (17%) were differentially expression in AA tumors only. We identified six miRNAs of particular interest, miR-7, miR-124, miR-129, miR-137, miR-139 and miR-218, which were down-regulated in both AAs and GBMs at a more stringent level of significance. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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