| Details |
| Disease Name | Alzheimer Disease |
| Nocoding RNA Name | hsa-miR-132 |
| Expression Pattern | down-regulated |
| Species | Homo sapiens |
| Detection Methods | sequencing,microarray,RT-PCR,Western Blot,Luciferase Reporter Assay,transfection,Immunofluorescence,ELISA etc. |
| Target | ITPKB |
| Tissue | Hippocampal and Prefrontal cortex tissue |
| Treatment | N/A |
| PubMed ID | 27485122 |
| Year | 2016 |
| Detail Description | MiR-132 loss exacerbates both amyloid and TAU pathology via inositol 1,4,5-trisphosphate 3-kinase B (ITPKB) upregulation in an AD mouse model.This leads to increased ERK1/2 and BACE1 activity and elevated TAU phosphorylation.We confirm downregulation of miR-132 and upregulation of ITPKB in three distinct human AD patient cohorts. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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