| Details |
| Disease Name | Supranuclear Palsy, Progressive |
| Nocoding RNA Name | hsa-miR-132 |
| Expression Pattern | expressed |
| Species | Homo sapiens |
| Detection Methods | qRT-PCR,transfections,Western Blot etc. |
| Target | PTBP2 |
| Tissue | Tau transfected Neuro2A cells |
| Treatment | N/A |
| PubMed ID | 21807765 |
| Year | 2011 |
| Detail Description | we chose five brain miRNAs, namely miR-9, miR-124, miR-132, miR-137 and miR-153, predicted to target PTBP1 and PTBP2 as well as six other genes, and expressed these in Neuro2a cells. Forty-eight hours posttransfection, western blot analysis was performed using 3R-tau, 4R-tau and tauC (total tau) antibodies. Surprisingly, all candidate miRNAs significantly affected 3R-tau and 4R-tau expression, albeit at different levels. While miR-9, miR-124, miR-132, miR-137 and miR-153 increased the relative 3R-tau levels, miR-9, miR-132 and miR-137 decreased 4R-tau. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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