| Details |
| Disease Name | Medulloblastoma |
| Nocoding RNA Name | hsa-miR-135a-2 |
| Expression Pattern | mutated |
| Species | Homo sapiens |
| Detection Methods | singlestrand conformational polymorphism (SSCP),Luciferase Reporter Assay etc. |
| Target | N/A |
| Tissue | brain(brain tumor tissue) |
| Treatment | N/A |
| PubMed ID | 21793975 |
| Year | 2012 |
| Detail Description | Differential PCR revealed deletions in miR-186 (15%), miR-135a-1(33%), miR-548d-1 (42%), miR-548d-2 (21%) and miR-512-2(33%) in the 48 medulloblastomas analyzed. Deletions or amplifications were found in miR-135b (23%) and miR-135a-2(15%). For miR-33b, deletion, amplification or a pointmutation (a G to A substitution at 76 nt in precursor miR-33b; 41 bp downstream of the mature miR-33b) were detected in five (10%) medulloblastomas.Targeting of the MYCC gene by miR-512-2 was confirmed by a reporter assay for luciferase activity. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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