NSDNA: The Nervous System Disease NcRNAome Atlas

Details

Disease Name	Supranuclear Palsy, Progressive
Nocoding RNA Name	hsa-miR-137
Expression Pattern	expressed
Species	Homo sapiens
Detection Methods	qRT-PCR,transfections,Western Blot etc.
Target	N/A
Tissue	Tau transfected Neuro2A cells
Treatment	N/A
PubMed ID	21807765
Year	2011
Detail Description	we chose five brain miRNAs, namely miR-9, miR-124, miR-132, miR-137 and miR-153, predicted to target PTBP1 and PTBP2 as well as six other genes, and expressed these in Neuro2a cells. Forty-eight hours posttransfection, western blot analysis was performed using 3R-tau, 4R-tau and tauC (total tau) antibodies. Surprisingly, all candidate miRNAs significantly affected 3R-tau and 4R-tau expression, albeit at different levels. While miR-9, miR-124, miR-132, miR-137 and miR-153 increased the relative 3R-tau levels, miR-9, miR-132 and miR-137 decreased 4R-tau.

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