| Disease Name |
Glioblastoma |
| Nocoding RNA Name |
hsa-miR-138 |
| Expression Pattern |
down-regulated |
| Species |
Homo sapiens |
| Detection Methods |
Real-time PCR, Luciferase Reporter Assay,Immunohistochemistry,Western Blot etc. |
| Target |
E2F2 |
| Tissue |
brain(brain tumor tissue) |
| Treatment |
N/A
|
| PubMed ID |
23707559 |
| Year |
2013 |
| Detail Description |
miRNA-138 is reduced in both GBM clinical specimens and cell lines, and is effective to inhibit EZH2 expression.Mechanism investigation reveals that miRNA-138 acquires tumor inhibition through directly targeting EZH2, CDK6, E2F2 and E2F3. |
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