NSDNA: The Nervous System Disease NcRNAome Atlas

Details

Disease Name	Glioblastoma
Nocoding RNA Name	hsa-miR-142-3p
Expression Pattern	expressed
Species	Homo sapiens
Detection Methods	Methylation-Specific PCR,Sequencing etc.
Target	HMGA2
Tissue	glioblastoma cell lines
Treatment	N/A
PubMed ID	24332177
Year	2013
Detail Description	interleukin-6 (IL-6) inhibits miR142-3p expression and promotes GBM propagation by inducing DNA methyltransferase 1-mediated hypermethylation of the miR142-3p promoter. Interestingly,miR142-3p also suppresses IL-6 secretion by targeting the 3-UTR of IL-6. In addition, miR142-3p also targets the 3-UTR and suppresses the expression of high-mobility group AT-hook 2 (HMGA2), leading to inhibition of Sox2-related stemness.

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