| Details |
| Disease Name | Glioma |
| Nocoding RNA Name | hsa-miR-145 |
| Expression Pattern | down-regulated |
| Species | Homo sapiens |
| Detection Methods | qRT-PCR,Luciferase Reporter Assay etc. |
| Target | CTGF |
| Tissue | brain(brain tumor tissue) |
| Treatment | N/A |
| PubMed ID | 23390502 |
| Year | 2013 |
| Detail Description | the expression of miR-145 was significantly lower in all the glial tumors that were examined compared to normal brain. A similar expression pattern was found for miR-143 that is a cluster partner of miR-145.the 3'-UTR domain of the CTGF mRNA is partially complementary tomiR-145. Using a luciferase reporter system in which the 3'-UTR of the CTGF was cloned downstream of a luciferase gene (pEZXMT01::CTGF-39UTR) we demonstrated that miR-145 significantly decreased the luciferase activity of this construct in U251 cells, whereas a control miRNA had no significant effect. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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