| Details |
| Disease Name | Glioblastoma |
| Nocoding RNA Name | hsa-miR-146b-5p |
| Expression Pattern | down-regulated |
| Species | Homo sapiens |
| Detection Methods | Real-time PCR,Luciferase Reporter Assay,Western Blot etc. |
| Target | EGFR |
| Tissue | brain |
| Treatment | N/A |
| PubMed ID | 26223576 |
| Year | 2015 |
| Detail Description | we identified four miRNAs (miR-107, miR-146b-5p, miR-346, miR-1287-5p) whose expression was frequently down-regulated in anaplastic astrocytomas and/or glioblastomas. Expression analyses of miRNA overexpressing glioma cells and 3'-untranslated region luciferase reporter gene assays revealed evidence that these miRNAs post-transcriptionally regulate expression of glioma-relevant genes, including CDK6 (miR-107), EGFR (miR-146b-5p, miR-1287-5p), TERT and SEMA6A (miR-346), all of which are overexpressed in malignant gliomas in situ. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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