| Details |
| Disease Name | Chorea |
| Nocoding RNA Name | hsa-miR-148a |
| Expression Pattern | differentially expressed |
| Species | Homo sapiens |
| Detection Methods | Real-time PCR, Luciferase Reporter Assay, Northern Blot, Western Blot etc. |
| Target | HTT |
| Tissue | cell line(HEK293T) |
| Treatment | N/A |
| PubMed ID | 23965969 |
| Year | 2013 |
| Detail Description | In this paper, we demonstrated that miRNAs regulate the expression of the HTT gene, whose mutation leads to Huntington’s disease (HD), a hereditary degenerative disorder. Specifically, we validated the interactions of canonical miRNAs, miR-137, miR-214, and miR-148a, with the HTT 3'UTR using a luciferase assay.Moreover, we applied synthetic miRNA mimics to examine whether a slight shifting of miRNA seed regions might alter the regulation of the HTT transcript. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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