Details
Disease Name Huntington Disease
Nocoding RNA Name hsa-miR-148a
Expression Pattern up-regulated
Species Homo sapiens
Detection Methods qRT-PCR,Luciferase Reporter Assay etc.
Target HTT
Tissue cell line(STHdh Q111/Hdh Q111 cell line)
Treatment N/A
PubMed ID 23965969
Year 2013
Detail Description both miR-214 and miR-148a were upregulated in STHdh Q111/Hdh Q111 cells,Moreover, miR-137 is highly expressed in the nervous system, suggesting the involvement/potential role of this miRNA in the pathogenesis of HD.Moreover, we applied synthetic miRNA mimics to examine whether a slight shifting of miRNA seed regions might alter the regulation of the HTT transcript.

 

NSDNA: The Nervous System Disease NcRNAome Atlas

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