| Details |
| Disease Name | Gait Ataxia |
| Nocoding RNA Name | hsa-miR-181a |
| Expression Pattern | up-regulated |
| Species | Homo sapiens |
| Detection Methods | microarray etc. |
| Target | N/A |
| Tissue | cell line(lymphoblast, fibroblast) |
| Treatment | N/A |
| PubMed ID | 22764244 |
| Year | 2012 |
| Detail Description | Here we report that hsa-miR-886-3p (miR-886-3p) was increased in patient cells as well as peripheral patient blood samples. Selective reduction in miR-886-3p by an anti-miR led to elevation of FXN message and protein levels without associated changes in histone marks at the FXN locus. Nevertheless, derepression of frataxin by a histone deacetylase inhibitor leads to a decrease in miR-886-3p. These results outline involvement of a small RNA, miR-886-3p in FRDA and a novel therapeutic approach to this disease using an anti-miR-886-3p. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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