| Details |
| Disease Name | Medulloblastoma |
| Nocoding RNA Name | hsa-miR-18a |
| Expression Pattern | up-regulated |
| Species | Homo sapiens |
| Detection Methods | Taqman Low Density Array etc. |
| Target | N/A |
| Tissue | brain(brain tumor tissue) |
| Treatment | N/A |
| PubMed ID | 21358093 |
| Year | 2010 |
| Detail Description | the most robust miRNA signature with 16 miRNAs differentially expressed as compared to the normal cerebellar tissues as well as all other subtypes. A number of miRNAs like miR-193a, miR-224/miR-452 cluster, miR-182/miR-183/miR-96 cluster, miR-365, miR-135a, miR-148a, miR-23b/miR-24/miR-27b cluster, miR-204, miR-146b, miR-449/miR-449b cluster, miR-335, and miR-328 are overexpressed by 3-100 fold almost exclusively in tumors associated with the WNT signaling pathway.Real time RT-PCR analysis confirmed significant overexpression of miR-224, miR-193a, miR-365, miR-148a, miR-182,and miR-23b in the WNT signaling associated medulloblastomas. miR-224 and miR-452 belong to a single cluster located in the intron of GABRE gene coding for GABA receptor. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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