| Details |
| Disease Name | Glioblastoma |
| Nocoding RNA Name | hsa-miR-196a |
| Expression Pattern | up-regulated |
| Species | Homo sapiens |
| Detection Methods | Quantitative Real-time PCR,immunohistochemistry,Luciferase Reporter Assay etc. |
| Target | NF-kB |
| Tissue | brain(brain tumor tissue) |
| Treatment | N/A |
| PubMed ID | 24463357 |
| Year | 2014 |
| Detail Description | We present for the first time evidence that miR-196a could directly interact with IkBa 3′-UTR to suppress IkBa expression and subsequently promote activation of NF-kB, consequently promoting proliferation of and suppressing apoptosis in GBM cells both in vitro and in vivo. Our study confirmed that miR-196a was upregulated in GBM specimens and that high levels of miR-196a were significantly correlated with poor outcome in a large cohort of GBM patients. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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