| Details |
| Disease Name | Glioblastoma |
| Nocoding RNA Name | hsa-miR-19a |
| Expression Pattern | up-regulated |
| Species | Homo sapiens |
| Detection Methods | RT-PCR,Luciferase Reporter Assay,Western Blot etc. |
| Target | CTGF |
| Tissue | brain(brain tumor tissue) |
| Treatment | N/A |
| PubMed ID | 20305691 |
| Year | 2010 |
| Detail Description | To analyse the expression of the miR-17-92 cluster, we performed real-time stem-loop RT-PCR of miRNAs in primary human astrocytic glioma tissue specimens and in non-neoplastic brain control tissues. Expression levels of miR-17-3p were significantly higher in primary Glioblastoma (GBIV) relative to non-neoplastic brain. Expression levels of miR-17-3p, miR-17-5p, miR-92a-1 and miR-106b were significantly higher in secondary GBIV relative to non-neoplastic brain. mir-19a and mir-19b were expressed at lower levels compared with the nonneoplastic brain. miR-17-5p, miR-19a and miR-106b showed a significantly higher expression in secondary GBIV specimens compared with astrocytoma grade II specimens.The CTGF gene was shown to be a target of miR-17-92 in glioblastoma spheroids by luciferase reporter assays. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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