| Details |
| Disease Name | Glioblastoma |
| Nocoding RNA Name | hsa-miR-21 |
| Expression Pattern | up-regulated |
| Species | Homo sapiens |
| Detection Methods | Real-time RT-PCR etc. |
| Target | LRRFIP1 |
| Tissue | glioblastoma cell lines(U373 MG) |
| Treatment | N/A |
| PubMed ID | 19559015 |
| Year | 2009 |
| Detail Description | miR-21 mediated chemoresistance to the chemotherapeutic agent VM-26 in glioblastoma cells and sought to identify the candidate target genes for miR-21 by gene expression profiling. Here we report that miR-21 was involved in mediating chemoresistance to VM-26 in glioblastoma cells. Suppression of miR-21 by specific antisense oligonucleotides in glioblastoma cell U373 MG led to enhanced cytotoxicities of VM-26 against U373 MG cells. We further identified and validated LRRFIP1, whose product is an inhibitor of NF-κB signaling, as a direct target gene of miR-21. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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