NSDNA: The Nervous System Disease NcRNAome Atlas

Details

Disease Name	Glioblastoma
Nocoding RNA Name	hsa-miR-21
Expression Pattern	up-regulated
Species	Homo sapiens
Detection Methods	RT-PCR, MTT assay,cell cycle analysis,apoptosis analysis etc.
Target	N/A
Tissue	glioblastoma cell lines
Treatment	N/A
PubMed ID	22709411
Year	2012
Detail Description	MTT assay, cell cycle analysis, and apoptosis analysis showed that reduction of miR-21 inhibited cell growth in U87 and LN229 GBM cells. Further, reduction of miR-21 decreased the expression of human telomerase reverse transcriptase (hTERT) and repressed STAT3 expression and STAT3 phosphorylation. STAT3 inhibition led to a remarkable depletion of hTERT at both mRNA and protein levels by binding to the hTERT gene promoter by performing luciferase reporter assay and chromatin Immunoprecipitation PCR.

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