| Details |
| Disease Name | Glioblastoma |
| Nocoding RNA Name | hsa-miR-21 |
| Expression Pattern | up-regulated |
| Species | Homo sapiens |
| Detection Methods | microarray,qRT-PCR etc. |
| Target | SPRY1 |
| Tissue | glioblastoma cell lines |
| Treatment | N/A |
| PubMed ID | 24155920 |
| Year | 2013 |
| Detail Description | A number of changes in the levels of microRNAs were detected in differentiating GICs, including overexpression of hsa-miR-21, hsa-miR-29a, hsa-miR-29b, hsa-miR-221 and hsa-miR-222, and down-regulation of hsa-miR-93 and hsa-miR-106a. Functional studies showed that miR-21 over-expression in GICs induced comparable cell differentiation features and targeted SPRY1 mRNA, which encodes for a negative regulator of neural stem-cell differentiation.miR-29a and miR-29b targeted MCL1 mRNA in GICs and increased apoptosis. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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