| Details |
| Disease Name | Glioblastoma |
| Nocoding RNA Name | hsa-miR-21 |
| Expression Pattern | up-regulated |
| Species | Homo sapiens |
| Detection Methods | Real-time RT-PCR,Western Blot,Luciferase Reporter Assay etc. |
| Target | VHL |
| Tissue | glioblastoma cell lines |
| Treatment | nimotuzumab |
| PubMed ID | 24012640 |
| Year | 2014 |
| Detail Description | miR-21 directly targets von Hippel-Lindau (VHL) and peroxisome-proliferator-activated receptora(PPARa) and that miR-21 regulates EGFR/AKT signaling through VHL/b-catenin and the PPARa/AP-1 axis. Further,the expression of miR-21 is regulated by EGFR via the activation of b-catenin and AP-1.We also show that the combination of nimotuzumab and an inhibitor of miR-21 is superior to single-agent therapy. |
NSDNA: The Nervous System Disease NcRNAome Atlas
Contact wanglh211@163.com for inquiries and feedback
© All right reserved 2016