| Details |
| Disease Name | Medulloblastoma |
| Nocoding RNA Name | hsa-miR-218 |
| Expression Pattern | down-regulated |
| Species | Homo sapiens |
| Detection Methods | Quantitative RT-PCR,Western Blot,Luciferase Reporter Assay etc. |
| Target | CDK6 |
| Tissue | brain(brain tumor tissue) |
| Treatment | N/A |
| PubMed ID | 23212916 |
| Year | 2013 |
| Detail Description | To investigate the role of miR-218 in medulloblastoma, we first measured mature miR-218 expression by quantitative RT-PCR in a small cohort of pediatric medulloblastoma patient samples and normal pediatric cerebellum. miR-218 expression was significantly lower in our patient samples. Next we evaluated miR-218 expression in a large cohort of 90 patient samples Recent genomic analysis showed four distinct subgroups of medulloblastoma. The four subgroups are WNT signaling(WNT), Sonic Hedgehog (SHH), Group 3, and Group 4.miR-218 expression was significantly down in the SHH group compared with adult cerebellum and Group 3 compared with adult cerebellum. Similar down-regulation of miR-218 expression was observed in well characterized medulloblastoma cell lines.Additional work further confirmed CDK6, RICTOR, and CTSB(cathepsin B) as targets of miR-218 and examined the functional role of one of these targets,CDK6, in medulloblastoma. |
NSDNA: The Nervous System Disease NcRNAome Atlas
Contact wanglh211@163.com for inquiries and feedback
© All right reserved 2016