| Details |
| Disease Name | Medulloblastoma |
| Nocoding RNA Name | hsa-miR-22 |
| Expression Pattern | down-regulated |
| Species | Homo sapiens |
| Detection Methods | Quantitative RT-PCR,fluorescence in situhybridization,Western Blot,Luciferase Reporter Assay etc. |
| Target | N/A |
| Tissue | medulloblastoma cell lines |
| Treatment | N/A |
| PubMed ID | 24576181 |
| Year | 2014 |
| Detail Description | Quantitative RT-PCR revealed significantly lower expression of miR-22 in 19/27(70%)medulloblastomas, D341,DAOY, ONS-76 medulloblastoma cell lines, compared to normal cerebellum. Quantitative RT-PCR revealed PAPST1 up-regulation in 18/27(67%)medulloblastomas. In addition, a luciferase reporter assay in ONS-76 and DAOY cells suggested that miR-22 directly targets the PAPST1 gene, and lentivirus-mediated knock-down of PAPST1 suppressed proliferation of DAOY and ONS-76 medulloblastoma cells. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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