| Details |
| Disease Name | Leukodystrophy, Metachromatic |
| Nocoding RNA Name | hsa-miR-23 |
| Expression Pattern | up-regulated |
| Species | Homo sapiens |
| Detection Methods | Luciferase Reporter Assay, Northern Blot and Quantitative RT-PCR etc. |
| Target | LMNB1 |
| Tissue | brain |
| Treatment | N/A |
| PubMed ID | 19259393 |
| Year | 2009 |
| Detail Description | Duplication of the gene encoding lamin B1 (LMNB1) with increased mRNA and protein levels hsa been shown to cause severe myelin loss in the brains of adult-onset autosomal dominant leukodystrophy patients. microRNAmiR-23 as a negative regulator of lamin B1 that can ameliorate the consequences of excessive lamin B1 at the cellular level. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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