| Details |
| Disease Name | Glioblastoma |
| Nocoding RNA Name | hsa-miR-296-3p |
| Expression Pattern | down-regulated |
| Species | Homo sapiens |
| Detection Methods | Western Blot,RT-PCR,immunohistochemistry etc. |
| Target | EAG1 |
| Tissue | brain(brain tumor tissue) |
| Treatment | N/A |
| PubMed ID | 22999387 |
| Year | 2013 |
| Detail Description | miR-296-3p was down-regulated in U251AR cells, concurrent with the up-regulation of EAG1 protein, compared with the parental U251 cell line.In vitrodrug sensitivity assay demonstrated that over-expression of miR-296-3p sensitised glioblastoma (GBM) cells to anticancer drugs,whereas down-expression using antisense oligonucleotides conferred MDR. Ectopic expression of miR-296-3p reduced EAG1 expression and suppressed cell proliferation drug resistance, and the luciferase activity of an EAG1 3-untranslated region-based reporter construct in U251AR cells, whereas EAG1 over-expression rescued the suppressive effect of miR-296-3p in U251AR cells. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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