| Details |
| Disease Name | Glioblastoma |
| Nocoding RNA Name | hsa-miR-29b |
| Expression Pattern | differentially expressed |
| Species | Homo sapiens |
| Detection Methods | Quantitative RT-PCR,Western Blot,Luciferase Reporter Assay etc. |
| Target | DNMT3A |
| Tissue | Human glioblastoma cell lines (U87MG) |
| Treatment | N/A |
| PubMed ID | 25625222 |
| Year | 2015 |
| Detail Description | miR-29s effectively blocked DNMT3A and 3B expression by degrading their mRNAs in U87MG glioblastoma cell line. Exogenous miR-29s substantially inhibited the proliferation, migration and invasion of U87MG cells, and promoted their apoptosis. These effects could be perfectly mimicked by a small interfering RNA against DNMT3A and 3B, and partially compromised by DNMT3A/3B expression plasmids co-transfection. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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