| Details |
| Disease Name | Myotonic Dystrophy |
| Nocoding RNA Name | hsa-miR-29b |
| Expression Pattern | down-regulated |
| Species | Homo sapiens |
| Detection Methods | qPCR, in situ hybridization, immunostaining etc. |
| Target | N/A |
| Tissue | muscle(cardiac and skeletal muscle tissues) |
| Treatment | N/A |
| PubMed ID | 21169019 |
| Year | 2011 |
| Detail Description | We found that miR-1 and miR-335 were up-regulated, whereas miR-29b and c, and miR-33 were down-regulated in DM1 biopsies compared to controls. We also found that the cellular distribution of muscle specific miR-1, miR-133b and miR-206 was severely altered in DM1 skeletal muscles. MicroRNA dysregulation was likely functionally relevant, since it impacted on the expression of the predicted miR-1, and miR-29 targets. The observed miRNA dysregulations and myslocalizations may contribute to DM1 pathogenetic mechanisms. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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