| Details |
| Disease Name | Glioblastoma |
| Nocoding RNA Name | hsa-miR-331-3p |
| Expression Pattern | down-regulated |
| Species | Homo sapiens |
| Detection Methods | Cell culture,RT-qPCR,Western Blot,transfection etc. |
| Target | NRP-2 |
| Tissue | glioblastoma cell lines |
| Treatment | N/A |
| PubMed ID | 24142150 |
| Year | 2014 |
| Detail Description | miR-331-3p expression in GBM cell lines is significantly lower than in normal brain, and that transient overexpression of miR-331-3p inhibits GBM cell line proliferation and clonogenic growth, suggesting a possible tumor suppressor role for miR-331-3p in this system.Using transfection studies, we validated NRP-2 mRNA as a target of miR-331-3p in GBM cell lines, and show that NRP-2 expression is regulated by miR-331-3p. RNA interference (RNAi) to inhibit NRP-2 expression in vitro decreased the growth and clonogenic growth of GBM cell lines, providing further support for an oncogenic role for NRP-2 in high-grade gliomas. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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