| Details |
| Disease Name | Glioblastoma |
| Nocoding RNA Name | hsa-miR-340 |
| Expression Pattern | down-regulated |
| Species | Homo sapiens |
| Detection Methods | Real-time PCR,Western Blot,Luciferase Reporter Assay etc. |
| Target | cyclin-D1 |
| Tissue | brain |
| Treatment | N/A |
| PubMed ID | 25817794 |
| Year | 2015 |
| Detail Description | miR-340 is downregulated in human glioblastoma tissue samples and several established glioblastoma cell lines. Proliferation and neurosphere formation assays revealed that miR-340 plays an oncosuppressive role in glioblastoma, and that its ectopic expression causes significant defect in glioblastoma cell growth. Further, using bioinformatics, luciferase assay and western blot, we found that miR-340 specifically targets the 3'UTRs of CDK6, cyclin-D1 and cyclin-D2, leading to the arrest of glioblastoma cells in the G0/G1 cell cycle phase. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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