Details
Disease Name Medulloblastoma
Nocoding RNA Name hsa-miR-34a
Expression Pattern down-regulated
Species Homo sapiens
Detection Methods Real-time PCR,Transient transfection,ELISA,Western Blot etc.
Target SIRT1
Tissue brain(brain tumor tissue)
Treatment N/A
PubMed ID 25348795
Year 2015
Detail Description Analysis of miR-34a expression in human medulloblastomas and medulloblastoma cell lines revealed significantly lower levels than in normal human cerebellum. Re-expression of miR-34a in human medulloblastoma cells reduced cell viability and proliferation, induced apoptosis and downregulated the miR-34a target genes, MYCN and SIRT1.

 

NSDNA: The Nervous System Disease NcRNAome Atlas

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