Details
Disease Name Glioblastoma
Nocoding RNA Name hsa-miR-34a
Expression Pattern down-regulated
Species Homo sapiens
Detection Methods Quantitative RT-PCR,Luciferase Reporter Assay etc.
Target N/A
Tissue glioblastoma cell lines
Treatment N/A
PubMed ID 21743299
Year 2011
Detail Description microRNa-34a (miR-34a) is significantly downregulated in glioblastoma multiforme (GBM) specimens compared with normal brain tissues. Growth curve and colony formation assays revealed that miR-34a suppresses proliferation of U373MG and ShG44 glioblastoma cells. Overexpression of miR-34a could induce apoptosis of glioblastoma cells. also, we identified notch1as a direct target gene of miR-34a.

 

NSDNA: The Nervous System Disease NcRNAome Atlas

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