| Details |
| Disease Name | Glioblastoma |
| Nocoding RNA Name | hsa-miR-377 |
| Expression Pattern | down-regulated |
| Species | Homo sapiens |
| Detection Methods | Real-time RT-PCR,Western Blot,Luciferase Reporter Assay etc. |
| Target | Sp1 |
| Tissue | brain(brain tumor tissue) |
| Treatment | N/A |
| PubMed ID | 24951112 |
| Year | 2014 |
| Detail Description | MiR-377 was markedly downregulated in human GBM tissues and cell lines. Overexpression of miR-377 dramatically inhibited cell growth both in culture and in orthotopic xenograft tumor models, blocked G1/S transition, and suppressed cell invasion in GBM cells. Importantly, introduction of miR-377 could strongly inhibit tumor growth in a subcutaneous GBM model. Subsequent investigation revealed that specificity protein 1 (Sp1) was a direct and functional target of miR-377 in GBM cells. |
NSDNA: The Nervous System Disease NcRNAome Atlas
Contact wanglh211@163.com for inquiries and feedback
© All right reserved 2016