| Details |
| Disease Name | Medulloblastoma |
| Nocoding RNA Name | hsa-miR-383 |
| Expression Pattern | down-regulated |
| Species | Homo sapiens |
| Detection Methods | Real-time RT-PCR,Luciferase Reporter Assay,Western Blot etc. |
| Target | PRDX3 |
| Tissue | brain(brain tumor tissue) |
| Treatment | N/A |
| PubMed ID | 23227829 |
| Year | 2013 |
| Detail Description | we demonstrated significant downregulation of miR-383 in 23/29 (79%) MB samples and 7/7 (100%) MB cells lines. Ectopic expression of miR-383 in MB cells led to suppression of cell growth, cell accumulation at sub-G1 phsae and alteration of apoptosis-related proteins. By transcriptomic analysis and computational algorithms, we identified peroxiredoxin 3 (PRDX3) as a target gene of miR-383. Luciferase reporter assay confirmed that miR-383 negatively regulated PRDX3 by interaction between miR-383 and complementary sequences in the 3′ UTR of PRDX3. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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