NSDNA: The Nervous System Disease NcRNAome Atlas

Details

Disease Name	Ataxia Telangiectasia
Nocoding RNA Name	hsa-miR-421
Expression Pattern	expressed
Species	Homo sapiens
Detection Methods	Real-time qPCR,Luciferase Reporter Assay,Transcription etc.
Target	ATM
Tissue	HeLa cell lines
Treatment	N/A
PubMed ID	20080624
Year	2010
Detail Description	we show that a human microRNA, miR-421, suppresses ATM expression by targeting the 3′-untranslated region (3′UTR) of ATM transcripts. Ectopic expression of miR-421 resulted in S-phase cell cycle checkpoint changes and an increased sensitivity to ionizing radiation, creating a cellular phenotype similar to that of cells derived from ataxiatelangiectasia (A-T) patients.

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