| Details |
| Disease Name | Amyotrophic Lateral Sclerosis |
| Nocoding RNA Name | hsa-miR-4299 |
| Expression Pattern | down-regulated |
| Species | Homo sapiens |
| Detection Methods | microarray,RT-qPCR etc. |
| Target | EPHA4 |
| Tissue | plasma |
| Treatment | N/A |
| PubMed ID | 26497046 |
| Year | 2015 |
| Detail Description | Three of the miRNAs were up-regulated and six were down-regulated significantly in the discovery cohort. Since an internal control is required as a sample stability indicator of both the patients and controls in microarray analysis, we selected the miRNA showing the smallest dispersion and equivalency between the two groups’mean value, and decided to use hsa-miR-4516. We found hsa-miR-4649-5p to be up-regulated, and hsa-miR-4299 to be down-regulated,where each was not influenced by clinical characteristics. EPHA4, a target gene linked to the nervous system which has also been reported to be a disease modifier of ALS, is the common and most notable target gene of hsa-miR-4649-5p and hsa-miR-4299. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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