| Details |
| Disease Name | Neurofibromatosis 1 |
| Nocoding RNA Name | hsa-miR-486-3p |
| Expression Pattern | up-regulated |
| Species | Homo sapiens |
| Detection Methods | microarray, qRT-PCR etc. |
| Target | PTEN |
| Tissue | tumor tissue |
| Treatment | N/A |
| PubMed ID | 23848554 |
| Year | 2013 |
| Detail Description | To comprehensively characterize the role of microRNAs in NF1 tumorigenesis, we analyzed 377 miRNAs expression in a large panel of dermal and plexiform neurofibromas, and MPNSTs. The most significantly upregulated miRNA in plexiform neurofibromas was miR-486-3p that targets the major tumor suppressor gene, PTEN. We confirmed PTEN downregulation at mRNA level. In plexiform neurofibromas, we also report aberrant expression of four miRNAs involved in the RAS-MAPK pathway (miR-370, miR-143, miR-181a, and miR-145). . |
NSDNA: The Nervous System Disease NcRNAome Atlas
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