| Details |
| Disease Name | Glioblastoma |
| Nocoding RNA Name | hsa-miR-500 |
| Expression Pattern | differentially expressed |
| Species | Homo sapiens |
| Detection Methods | TaqMan Low Density Array,MTT assay etc. |
| Target | N/A |
| Tissue | brain(brain tumor tissue) |
| Treatment | N/A |
| PubMed ID | 25322872 |
| Year | 2014 |
| Detail Description | The subsequent analysis revealed 28 significantly deregulated miRNAs in GBM tissue, which were able to precisely classify all examined samples. Correlation with clinical data led to identification of 6-miRNA signature significantly associated with progression free survival (HR 1.98, CI 95% [1.33-2.94], p<0.001) and overall survival (HR 2.86, CI 95% [1.91-4.29], p<0.001). MGMT methylation status was evaluated as reference method and risk score based on 6-miRNA signature indicated significant superiority in prediction of clinical outcome in GBM patients. Multivariate Cox analysis indicated that the risk score based on 6-miRNA signature is an independent prognostic classifier of GBM patients. We suggest that the risk score presents promising prognostic algorithm with potential for individualized treatment decisions in clinical management of GBM patients. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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