| Details |
| Disease Name | Glioblastoma |
| Nocoding RNA Name | hsa-miR-503 |
| Expression Pattern | down-regulated |
| Species | Homo sapiens |
| Detection Methods | transfection,qRT-PCR,Western Blot,Luciferase Reporter Assay etc. |
| Target | N/A |
| Tissue | glioblastoma cell lines |
| Treatment | N/A |
| PubMed ID | 24378652 |
| Year | 2014 |
| Detail Description | the expression of miR-503 was significantly reduced in GBM tissues and cell lines (U251 and U87MG) relative to normal brain tissues. Furthermore, our results demonstrated that overexpression of miR-503 in GBM cell lines not only suppressed cell proliferation through inducing G0/G1 cell cycle arrest and apoptosis, but also inhibited cancer cell migration and tumor invasion. In addition, we identified insulin-like growth factor-1 (IGF-1R) receptor mRNA is a bona fide target of miR-503 by computational analysis followed by luciferase reporter assays. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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