| Details |
| Disease Name | Glioblastoma |
| Nocoding RNA Name | hsa-miR-522 |
| Expression Pattern | up-regulated |
| Species | Homo sapiens |
| Detection Methods | Real-time qPCR,Luciferase Reporter Assay etc. |
| Target | PHLPP1 |
| Tissue | brain(brain tumor tissue) |
| Treatment | N/A |
| PubMed ID | 25776496 |
| Year | 2015 |
| Detail Description | Expression of miR-522 is markedly upregulated in GBM tissues and GBM cells compared with the matched non-tumor adjacent brain tissues (TAT) and normal human astrocytes (NHAs). In functional assays, miR-522 promoted GBM cell proliferation, which could be reversed by inhibitor of miR-522.We further identified PH domain leucine-rich repeats proteinphosphatase-1 (PHLPP1) as a putative target of miR-522, which is likely a main contributor to the promotion of tumor cell growth observed in our assays. |
NSDNA: The Nervous System Disease NcRNAome Atlas
Contact wanglh211@163.com for inquiries and feedback
© All right reserved 2016