Details
Disease Name Cerebral Amyloid Angiopathy, Familial
Nocoding RNA Name hsa-miR-582-3p
Expression Pattern mutated
Species Homo sapiens
Detection Methods Sanger sequencing,RT-QMPSF,RNA-binding protein immunoprecipitation etc.
Target APP
Tissue blood
Treatment N/A
PubMed ID 25828868
Year 2015
Detail Description We sequenced the 3’UTR of APP in 90 patients, we identified three sequence variants in four patients.miR-892b significantly downregulated APP expression, whereas the ΔTA variant blocked this effect. Interestingly, miR-582-3p caused an increase in APP expression only in the presence of the ΔTA variant.

 

NSDNA: The Nervous System Disease NcRNAome Atlas

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