| Disease Name |
Glioblastoma |
| Nocoding RNA Name |
hsa-miR-622 |
| Expression Pattern |
down-regulated |
| Species |
Homo sapiens |
| Detection Methods |
RT-PCR,Western Blot,Luciferase Reporter Assay etc. |
| Target |
K-Ras |
| Tissue |
brain |
| Treatment |
N/A
|
| PubMed ID |
26596833 |
| Year |
2015 |
| Detail Description |
We demonstrated that miR-622 expression was lower in tumor tissues and cells, when compared to normal brain tissues and normal human astrocyte (NHA) cells, while K-Ras messenger RNA (mRNA) and protein showed the opposite expression profile. we discovered that wild Kirsten rat sarcoma (K-Ras) was a direct target of miR-622, which decreased the expression of K-Ras protein in A172, U87, and U251 cells. |
|