| Details |
| Disease Name | Glioblastoma |
| Nocoding RNA Name | hsa-miR-648 |
| Expression Pattern | detectable |
| Species | Homo sapiens |
| Detection Methods | Cell transfections,Reporter gene assays,Quantitative Real-time PCR etc. |
| Target | MGMT |
| Tissue | brain(brain tumor tissue) |
| Treatment | N/A |
| PubMed ID | 23340988 |
| Year | 2013 |
| Detail Description | miR-181d,miR-767-3p, and miR-648 as significant post-transcriptional regulators of MGMT in glioblastomas; the first two miRNAs induce MGMT mRNA degradation, the latter affects MGMT protein translation.We next studied the expression of the three miRNAs regulating the long 3-UTR MGMT isoform in primary human GBM tissue specimen as compared to normal brain tissue.expression of miR-767-3p is strongly enhanced (10.1±1.9-fold), and miR-648 is up-regulated 2.1±0.4-fold, whereas miR-181d remains unchanged. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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