| Details |
| Disease Name | Glioblastoma |
| Nocoding RNA Name | hsa-miR-663 |
| Expression Pattern | down-regulated |
| Species | Homo sapiens |
| Detection Methods | RT-PCR,Luciferase Reporter Assay etc. |
| Target | TGF-beta1 |
| Tissue | brain |
| Treatment | N/A |
| PubMed ID | 26717894 |
| Year | 2016 |
| Detail Description | miR-663 was significantly downregulated in glioblastoma tissues (n=25), when compared to that in normal brain tissues (n=15). In addition, its expression levels were also reduced in human glioblastoma cell lines, A172 and U87. Furthermore, restoration of miR-663 expression led to a significant decrease in the cell proliferation, migration and invasion of human glioblastoma A172 and U87 cells. We further identified TGF-β1 as a direct target of miR-663, and found that the expression of TGF-β1 was negatively mediated by miR-663 at the post-transcriptional level in glioblastoma cells. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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