| Details |
| Disease Name | Glioblastoma |
| Nocoding RNA Name | hsa-miR-7 |
| Expression Pattern | down-regulated |
| Species | Homo sapiens |
| Detection Methods | Quantitative Real-time RT-PCR,Luciferase Reporter Assay,Cell proliferation assay etc. |
| Target | CDK6 |
| Tissue | brain(brain tumor tissue) |
| Treatment | N/A |
| PubMed ID | 19773441 |
| Year | 2009 |
| Detail Description | glioblastoma surgical specimens and normal brain tissue was analyzed for the first time by using quantitative RT-PCR. We found that the average level of miR-34 expression is lower in glioblastoma tissues (n=11) than in normal brain tissue (n=6).Transfection of miR-34a reduced the protein levels of c-Met protein in glioma and medulloblastoma cells and astrocytes. Transfection of miR-34a also reduced the protein levels of Notch-1, Notch-2, and CDK6 in glioma cells and stem cells. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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