NSDNA: The Nervous System Disease NcRNAome Atlas

Details

Disease Name	Medulloblastoma
Nocoding RNA Name	hsa-miR-9
Expression Pattern	down-regulated
Species	Homo sapiens
Detection Methods	qRT-PCR,methylation-specific PCR,Western Blot,immunofluorescence analysis etc.
Target	N/A
Tissue	medulloblastoma cell lines
Treatment	N/A
PubMed ID	24346283
Year	2014
Detail Description	Compared with normal human fetal cerebellum, a decreased expression level of miR-9 was observed in the majority of MB tumour tissues and in all the six MB cell lines tested. Low microRNA-9 expression correlates significantly with the diagnosis of unfavourable histopathological variants and with poor clinical outcome. microRNA-9 silencing occurs via cancer-specific CpG island hypermethylation. HES1 was identified as a direct target of microRNA-9 in medulloblastoma, and restoration of microRNA-9 was shown to trigger cell cycle arrest, to inhibit clonal growth and to promote medulloblastoma cell differentiation.

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