| Details |
| Disease Name | Medulloblastoma |
| Nocoding RNA Name | hsa-miR-935 |
| Expression Pattern | down-regulated |
| Species | Homo sapiens |
| Detection Methods | Taqman low density assay,qRT-PCR etc. |
| Target | TBC1D9 |
| Tissue | brain(brain tumor tissue) |
| Treatment | N/A |
| PubMed ID | 21931624 |
| Year | 2011 |
| Detail Description | miRNA profiles were generated for primary MB specimens, MB cell lines, CD133+NSCs and CD1332NPCs using qRT-PCR.clustering analysis based on the 50 most significantly differentially expressed miRNAs in both MB primary specimens and cell lines compared to CD133+NSCs was consistent with these findings.Significant upregulation of miR-935 was confirmed by qRT-PCR, with,11 000 fold up-regulation of miR-935 in pre-miR-935 transfected cells at 24 h compared to scrambled negative control cells.Significant down-regulation of three of the seven predicted miR-935 target genes was observed at the mRNA level Solute carrier family 5 member 3 (SLC5A3)(p = 0.0251), Hypothetical protein LOC9778 (KIAA0232)(p = 0.0004) and Zinc Finger AN1-type domain 6 (ZFAND6) (p = 0.0037). Furthermore, down-regulation of TBC domain family member 9 (TBC1D9) approached statistical significance (p = 0.064). |
NSDNA: The Nervous System Disease NcRNAome Atlas
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