Details
Disease Name Glioblastoma
Nocoding RNA Name hsa-miR-96
Expression Pattern up-regulated
Species Homo sapiens
Detection Methods Real-time qRT-PCR, Drug Uptake Assay,MTT assay,In Situ Wright Staining,Matrigel Invasion Assay etc.
Target N/A
Tissue glioblastoma cell lines
Treatment photodynamic therapy
PubMed ID 23409016
Year 2013
Detail Description photofrin based PDT followed by miR-99a transfection dramatically increased miR-99a expression and also increased apoptosis in glioblastoma cell cultures and drastically reduced tumor growth in athymic nude mice, due to down regulation of fibroblast growth factor receptor 3 (FGFR3) and PI3K/Akt signaling mechanisms leading to inhibition of cell proliferation and induction of molecular mechanisms of apoptosis.

 

NSDNA: The Nervous System Disease NcRNAome Atlas

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