NSDNA: The Nervous System Disease NcRNAome Atlas

Details

Disease Name	Neuroblastoma
Nocoding RNA Name	linc00467
Expression Pattern	up-regulated
Species	Homo sapiens
Detection Methods	microarray,Real-time RT-PCR,siRNA,chromatin immunoprecipitation,Luciferase Reporter Assay etc.
Target	N/A
Tissue	neuroblastoma cell lines
Treatment	N/A
PubMed ID	24586304
Year	2014
Detail Description	the microarray gene expression study showed that 5 lncRNAs were down-regulated, and 1 lncRNA was up-regulated, by N-Myc siRNA-1 within 30 hours by more than 2 fold. One of the lncRNAs most significantly upregulated by N-Myc siRNA-1 was linc00467.RT-PCR, chromatin immunoprecipitation and luciferase assays showed that N-Myc suppressed linc00467 gene expression through direct binding to thelinc00467 gene promoter and reducinglinc00467 promoter activity. While N-Myc suppressed the expression of RD3, the protein-coding gene immediately down-stream of linc00467 gene, through direct binding to the RD3 gene promoter and reducing RD3 promoter activity, linc00467 reduced RD3 mRNA expression.

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